Catalytic synthesis of P-chiral supramolecular phosphines, their self-assembled metal complexes and implication in asymmetric catalysis

Abstract

The thesis titled “Catalytic synthesis of P-chiral supramolecular phosphines, their self-assembled metal complexes and implication in asymmetric catalysis” is divided into six different chapters. Chapter-1 deals with the detailed literature survey on the chiral supramolecular phosphine ligands and their self-assembled metal complexes. Various chiral supramolecular phosphine ligand and their selfassembled metal complexes used in asymmetric catalysis such as hydrogenation and hydroformylation will be discussed.1 Synthetic aspects of all these chiral supramolecular phosphine ligands will be highlighted. 2 In addition to this, on the basis of backbone chirality, the chiral supramolecular phosphine ligands have been subdivided into two parts, 1) C-chiral backbone supramolecular phosphines, and 2) Axially chiral supramolecular phosphines. Chapter2 deals with the synthesis and characterization of (Me-Duphos)-Pd complexes and their application towards the enantioselective synthesis of P-chiral supramolecular phosphine. Chapter-3 describes the Pd-catalyzed synthesis of a library of P-chiral supramolecular phosphine ligands under mild conditions via enhancing the rate of P-C coupling reaction through rational catalyst selection. The nickel catalyzed synthesis of P-chiral supramolecular phosphine ligands is illustrated in Chapter4. Chapter-5 deals with the implication of P-chiral supramolecular phosphine ligands and their self-assembled metal complexes in asymmetric hydrogenation. Chapter-6 concludes the work and provides future direction.